Pramlintide is a amylin analog used for diabetes / appetite. Pramlintide is a synthetic version of amylin, a hormone released with insulin. In plain terms: taken at meals alongside insulin in diabetes, it blunts the post-meal blood-sugar spike and reduces hunger. It is FDA-approved.

How much water do I add to Pramlintide?

You can reconstitute Pramlintide with 0.5, 1, or 2 mL of bacteriostatic water. Each option produces a different concentration and syringe draw for the same dose. Use the calculator to see which is easiest to measure.

What does Pramlintide cost per dose?

Cost per dose depends on vial size, price paid, and your dose. Enter your vendor's price in the Pramlintide calculator to see cost per dose and monthly cost.

What is the reference dose for Pramlintide?

The commonly referenced range is 0.015 up to 0.12 mg per dose (start low, increase slowly), taken with meals. This is reference information, not a recommendation. Talk to a licensed clinician.

What are the side effects of Pramlintide?

Reported side effects of Pramlintide include: It can cause low blood sugar when used with insulin, plus nausea.. Severity and frequency vary by person and dose.

Who should not take Pramlintide?

Pramlintide is generally not appropriate for: Not being able to feel low blood sugar coming on (hypoglycemia unawareness); Severe stomach-emptying problems (gastroparesis); Pregnancy. Talk to a licensed clinician before starting.

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Decoding

Pramlintide_Dosage, benefits & legal status

Also known as Symlin

By the Peptide Decoding Editorial Team

Published July 22, 2026 · Updated July 25, 2026

An approved mealtime shot used with insulin to blunt blood-sugar spikes and hunger.

Diabetes / appetiteAmylin analogFDA-approved

InAmylin analogs

Common vial size5 mg

Dose0.015 up to 0.12 mg per dose (start low, increase slowly)

FrequencyWith meals

RouteUnder the skin (subcutaneous)

StatusFDA-approved

MixYour choice, calculate it

CycledNot cycled

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

What is Pramlintide?

Plain language first. The technical label stays, but it never stands alone.

Overview

Taken at meals alongside insulin in diabetes, it blunts the post-meal blood-sugar spike and reduces hunger. It is FDA-approved.

The technical version

Pramlintide is a synthetic version of amylin, a hormone released with insulin.

What it's used for

An approved mealtime shot used with insulin in diabetes. It blunts the blood-sugar spike after eating and reduces hunger.

How does Pramlintide work?

What it does in the body, and where.

Pramlintide copies amylin, and it was the first drug in this family, approved back in 2005 for use alongside insulin rather than for weight loss.

01
It replaces amylin, which is missing in type 1 diabetes
Amylin is released with insulin from the same cells, so people who cannot make insulin cannot make amylin either.
02
The after-meal blood sugar spike flattens
Its approved job: slowing stomach emptying and blunting the glucose surge that insulin alone handles poorly.
03
It must be injected separately from insulin
It cannot be mixed in the same syringe, which means extra injections at every meal and is the main reason uptake stayed low.

Receptors

Acts on one receptor.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Smoothing out blood sugar spikes after meals, used with insulin in type 1 or type 2 diabetes. This is its approved useFDA-approved
Appetite reduction and weight loss, which is an off-label reason it gets prescribedClinical use

The published record

Research index

554

Records indexed for Pramlintide400 papers and 64 trials indexed in detail.

337 in humans, 166 of them original studies.

64 registered trials, 15 with posted results.

Browse the records

In animalsPro

In the labPro

ReviewsPro

Senior author sharePro

Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.

Compound field notes

At a glance

Four things to know about Pramlintide

Evidence

FDA-approved

How much, and do you cycle it?

The range, and whether you take breaks.

0.015 up to 0.12 mg per dose (start low, increase slowly), with meals. Not cycledFDA label

Taken continuously for as long as it is working. Neither the label nor clinical practice describes an on/off schedule.

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

About 48 minutesFDA label

In healthy individuals. The main metabolite has a similar half-life and is active in vitro.

Source: Symlin label section 12.3, DailyMed setid 4aea30ff-eb0d-45c1-b114-3127966328ff

You can compare this against the whole library to see where it sits.

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)

Printed on the vial.

What you paid per vial

Used for cost per dose only.

Your dose (mcg)

Commonly referenced range: 0.015 up to 0.12 mg per dose (start low, increase slowly)FDA label

Choose your mix

0.5 mL water0.1units · 10 mg/mL

Half a 100-unit syringe

1 mL water0.3units · 5 mg/mL

One full 100-unit syringe

Easiest

2 mL water0.6units · 2.5 mg/mL

Two full 100-unit syringes

your own mL

units · —

Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

0.6 / 100 units

0.6 units is a very small line to read, so a small slip is a large error. A larger water volume above spreads the same dose across more units.

Full calculator with reorder date →Read a syringe →

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized Pramlintide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.

Not being able to feel low blood sugar coming on (hypoglycemia unawareness)
Severe stomach-emptying problems (gastroparesis)
Pregnancy

Stop and get help

These are emergencies. Seek care.

Signs of severe low blood sugar such as confusion, shaking, sweating, or fainting, which is the boxed warning on this drug
Severe or persistent vomiting
Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing

Common effects

Expected, and usually mild.

Nausea, especially when starting
Reduced appetite
Headache
Injection-site reactions

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is Pramlintide approved?

And where the numbers on this page come from.

Yes. Pramlintide is FDA approved and available on prescription in the United States.

Approval status
FDA-approved
Route
Under the skin (subcutaneous)
Checked
July 2026

What has happened recently

Carries a boxed warning for severe low blood sugar, particularly in type 1 diabetes, when used with insulin.

You can compare this against the whole library, or read how to check a seller.

DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
Vial sizeFrom what vendors typically list; not a recommendation.
Sources
FDA prescribing information, Symlin
Reviewed22 July 2026

What else is like Pramlintide?

Others in Amylin analogs, side by side.

If you're weighing Pramlintide, it's worth reading CagriSema, Petrelintide, and Eloralintide in the same class.

YOU ARE HERE

Pramlintide

An approved mealtime shot used with insulin to blunt blood-sugar spikes and hunger.

FDA-approved

Dose: 0.015 up to 0.12 mg per dose (start low, increase slowly)
How often: With meals

CAGSEM

CagriSema

A weekly two-in-one shot combining cagrilintide and semaglutide for bigger loss.

Investigational

Dose: 2.4 mg per week
How often: Weekly

PETRE

Petrelintide

An experimental weekly fullness-hormone shot for weight loss.

Investigational

Dose: 0.6 up to 9 mg per week (start low, increase slowly)
How often: Weekly

ELORA

Eloralintide

An experimental weekly fullness-hormone shot for weight loss.

Investigational

Dose: 1 up to 9 mg per week (trial doses)
How often: Weekly

See other amylin analogs

Guides for this compound

How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Semaglutide vs Tirzepatide vs Retatrutide
One receptor, two, or three. Mechanism, trial weight loss, side effects, and real cost.

Sources

FDA prescribing information, Symlin(2005)
FDA approval; label carries a boxed warning for severe low blood sugar.

Last reviewed 22 July 2026

Beyond these, 464 records are indexed. Browse the records