Acetyl Tetrapeptide-5 (Eyeseryl)_Dosage, benefits & legal status
Also known as Eyeseryl, acetyl tetrapeptide 5, Ac-beta-Ala-His-Ser-His
A topical peptide aimed at under-eye puffiness rather than lines.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Acetyl Tetrapeptide-5 (Eyeseryl)?
Plain language first. The technical label stays, but it never stands alone.Overview
A topical peptide for puffy under-eyes, not for wrinkles. Whether it helps depends on why your under-eyes are puffy in the first place.
Acetyl tetrapeptide-5 (Ac-beta-Ala-His-Ser-His), a topical cosmetic peptide developed by Lipotec and marketed as Eyeseryl for periorbital edema. Claimed activity relates to reduced fluid accumulation in periorbital tissue. Efficacy data is supplier-generated.
What it's used for
A topical peptide used in eye products for puffiness, bags and the look of dark circles.
How does Acetyl Tetrapeptide-5 (Eyeseryl) work?
What it does in the body, and where.Under-eye bags are usually fluid and fat, not wrinkles, so this peptide is aimed at a different problem from most of the category.
- 01The target is fluid retention under thin skinSkin under the eye is the thinnest on the body, so a small amount of retained fluid shows as a visible bag. The peptide is marketed as an anti-oedema active rather than an anti-wrinkle one.
- 02It sits in eye formulas at low percentagesUse levels come from formulation practice. There is no dose-ranging trial establishing how much is needed.
- 03Cause matters more than ingredient herePuffiness from sleep, salt or allergy behaves differently from inherited under-eye fat, and only the first kind is likely to respond to anything in a jar.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Reducing the look of under-eye puffiness, applied to the skinSupplement or cosmetic
- Dark circles, where puffiness is casting the shadowSupplement or cosmetic
- General skin smoothingnone
The published record
Papers and trials about Acetyl Tetrapeptide-5 (Eyeseryl)
1 papers tagged human · 0 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Acetyl Tetrapeptide-5 (Eyeseryl)
Evidence
Cosmetic
Category
Skin and cosmetic
Common vial
Varies
Half-life
Not measured, and not the right question
How much, and do you cycle it?
The range, and whether you take breaks.Serum, per product, daily. Not cycled Community practice
Used daily as part of a routine. The effect depends on continued use and returns to baseline when you stop, so there is nothing to cycle off.
Not measured, and not the right questionNo figure
This is a topical cosmetic ingredient. A blood half-life measures how fast something leaves the bloodstream, and these are not intended to reach it in meaningful amounts. What matters for a topical is how much penetrates the skin and how long it stays in the tissue, which is a different measurement and one that is rarely published.
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.Acetyl Tetrapeptide-5 (Eyeseryl) is not injected
It is taken on the skin (topical). Applied as a topical product at the concentration the manufacturer sets. There is no injected dose.
How do you store it?
Before mixing, and after.Room temperature, out of light. Cap it tight after each use.
Acetyl Tetrapeptide-5 (Eyeseryl) ships as a cream, gel, or serum. Keep it at room temperature away from sun and heat unless the label says otherwise. Refrigerating an emulsion can split the texture. Watch for color, smell, or separation changes and stop using it if any appear.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- A known allergy to this ingredient or to others in the same product
- Broken, cracked, or actively irritated skin
- Use right up to the lash line or inside the eye, since eye-area products are formulated to stay outside it
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- A rash that spreads beyond where you applied it
- Swelling of the face, lips, or eyelids, or any trouble breathing
- Burning that does not settle after rinsing it off
- Stinging, watering or redness in the eye itself
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Reactions are not commonly reported, though no published testing has looked for them. Irritation from a product containing it may come from anything else in the formula.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Acetyl Tetrapeptide-5 (Eyeseryl) approved?
And where the numbers on this page come from.Not as a medicine. Acetyl Tetrapeptide-5 (Eyeseryl) is sold without a prescription as a cosmetic ingredient, which is a different thing from being approved as a drug.
- Approval statusCosmeticSold without a prescription as an ingredient in cosmetics, such as skincare and hair products. The FDA does not approve cosmetics before they are sold, and being easy to buy says nothing about whether it works.
- RouteOn the skin (topical)
- Checked24 August 2026
- DoseFrom the concentration range manufacturers formulate at. This is a product strength, not a dose set by a regulator or a trial.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
Regulated as a cosmetic ingredient, not a drug. Cosmetic ingredients are not reviewed for effectiveness before sale in the US, so a product may legally claim an appearance benefit without a trial behind it.
You can compare this against the whole library, or read how to check a seller.
What else is like Acetyl Tetrapeptide-5 (Eyeseryl)?
Others in Skin and cosmetic, side by side.If you're weighing Acetyl Tetrapeptide-5 (Eyeseryl), it's worth reading Biotinoyl Tripeptide-1, Hexapeptide-11, and Melanotan III in the same class.
A topical peptide aimed at under-eye puffiness rather than lines.
- Dose
- Serum, per product
- How often
- Daily
GHK with a biotin tail, sold for hair and lashes rather than skin.
- Dose
- Serum, 2 to 6 ppm typical in a finished product
- How often
- Daily
A yeast-derived cosmetic peptide for elasticity, with a thin evidence trail.
- Dose
- Serum, per product
- How often
- Daily
A name sold on the research market with no molecule publicly attached to it.
- Dose
- Research only
- How often
- Not established
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 1 records are indexed. Browse the records