Semax is a acth(4-10) peptide. N-Acetyl Semax Amidate is a semax variant.
| Comparison | Semax ACTH 4-10 | N-Acetyl Semax Amidate NA Semax Amidate · NASA Semax |
|---|---|---|
| How it works | How it works Semax is seven amino acids based on a fragment of ACTH, a brain-signalling hormone, with the hormonal part removed. It is a nasal spray, and it is a registered medicine in Russia. | How it works This is Semax with two chemical modifications, an acetyl group at one end and an amide at the other, both added to slow its breakdown. |
| What it is | A peptide used for sharper focus, memory, and mental clarity. | A longer-lasting version of Semax for focus and memory. |
| Status | Research only | Research only |
| Typical dose | 0.2–0.6 mg per day | 0.2–0.4 mg per day |
| How often | 1-2x daily | 1-2x daily |
| Stays active | Minutes | Not established |
| Dose comes from | Published human study | Community practice |
| Cycled? | Taken in courses, usually 10 to 14 days, with breaks between Community practice | Taken in courses, usually 10 to 14 days, with breaks between Community practice |
| What it does | ||
| Drug class | ACTH(4-10) peptide | Semax variant |
| Used for | Sharpens focus, memory, and mental clarity by raising a brain-growth signal. It works within about half an hour and is used in Russia for stroke recovery and attention. | A longer-lasting, more stable version of Semax for focus, memory, and mental clarity. |
| Receptors hit | — | — |
| Numbers | ||
| Full dose line | 0.2 up to 0.6 mg per day | 0.2 up to 0.4 mg per day |
| Why that cycle | The Russian clinical literature uses course dosing rather than continuous use, and users report the effect fading if it is taken every day without a break. No controlled study has compared courses against continuous use. | Same course pattern as Semax, which it is a longer-lasting version of. No controlled study has compared courses against continuous use. |
| Weight / effect | Not measured in a trial | Not measured in a trial |
| Chain length | 7 residues | 7 residues |
| Common vial | 30 mg | 30 mg |
| Before you start | ||
| Route | Nasal spray, or injected under the skin | Nasal spray, or injected under the skin |
| Do not use if | No formal contraindications established outside Russia Pregnancy | No formal contraindications established outside Russia Pregnancy |
What separates them
Proof behind the dose. Semax has a dose from a published human study. N-Acetyl Semax Amidate has a range that comes from community practice, with no published human study behind it.
What doesn't differ: They are both taken the same way (nasal spray, or injected under the skin), aimed at the same thing (focus & brain) and on the same schedule (1-2x daily). Neither has a measured effect size from a published trial, so there is no number to rank them on.
What people actually report
Semax
- Mostly mild nasal irritation or occasional headache, reported from nasal use.
- No dependence has been reported.
- Effects from injection have not been studied.
- No serious adverse events have been reported at studied doses
- Signs of an allergic reaction
N-Acetyl Semax Amidate
- Mostly mild nasal irritation from nasal use.
- Effects from injection have not been studied.
- No serious adverse events have been reported at studied doses
- Signs of an allergic reaction
Side effects are what users and trials report most often, not a complete list. Anything sudden, spreading, or breathing-related is an emergency regardless of which compound caused it.
People also compare
This comparison does not cover cost, long-term safety, or how you personally will respond. Effect figures come from separate trials in different populations and are not always directly comparable to each other. Nothing here is medical advice or a recommendation to use any of these. Talk to a clinician about your own situation.