Selank is a tuftsin analog (nasal). N-Acetyl Semax Amidate is a semax variant (nasal).
They are aimed at different things: Selank at calm & anxiety; N-Acetyl Semax Amidate at focus & brain.
| Comparison | Selank TP-7 | N-Acetyl Semax Amidate NA Semax Amidate · NASA Semax |
|---|---|---|
| How it works | How it works Selank is a synthetic version of tuftsin, a natural peptide that sits at the junction of immune and brain signalling. | How it works This is Semax with two chemical modifications, an acetyl group at one end and an amide at the other, both added to slow its breakdown. |
| What it is | A nasal spray that eases anxiety while keeping you clear-headed. | A longer-lasting version of Semax for focus and memory. |
| Status | Research onlyResearch only (approved in Russia) | Research only |
| Typical dose | 0.25–0.5 mg per day | 0.2–0.4 mg per day |
| How often | 1-2x daily | 1-2x daily |
| Stays active | minutes (nasal) | Not established |
| Dose comes from | Published human study | Community practice |
| Cycled? | Taken in courses, usually 10 to 14 days, with breaks between Community practice | Taken in courses, usually 10 to 14 days, with breaks between Community practice |
| What it does | ||
| Drug class | Tuftsin analog (nasal) | Semax variant (nasal) |
| Used for | A nasal spray that eases anxiety and stress while keeping you clear-headed, without the sedation or dependence of anti-anxiety pills. It is often paired with Semax. | A longer-lasting, more stable version of Semax for focus, memory, and mental clarity. |
| Receptors hit | — | — |
| Numbers | ||
| Full dose line | 0.25 up to 0.5 mg per day | 0.2 up to 0.4 mg per day |
| Why that cycle | Course dosing follows the Russian clinical practice it comes from. No controlled study has compared it against continuous use. | Same course pattern as Semax, which it is a longer-lasting version of. No controlled study has compared courses against continuous use. |
| Weight / effect | Not measured in a trial | Not measured in a trial |
| Chain length | 7 residues | 7 residues |
| Common vial | 30 mg | 30 mg |
| Before you start | ||
| Route | Nasal spray | Nasal spray |
| Do not use if | No formal contraindications established outside Russia Pregnancy | No formal contraindications established outside Russia Pregnancy |
What separates them
Proof behind the dose. Selank has a dose from a published human study. N-Acetyl Semax Amidate has a range that comes from community practice, with no published human study behind it.
What doesn't differ: They are both taken the same way (nasal spray) and on the same schedule (1-2x daily). Neither has a measured effect size from a published trial, so there is no number to rank them on.
What people actually report
Selank
- Mostly mild nasal irritation; very well tolerated.
- Signs of an allergic reaction
N-Acetyl Semax Amidate
- Mostly mild nasal irritation.
- No serious adverse events have been reported at studied doses
- Signs of an allergic reaction
Side effects are what users and trials report most often, not a complete list. Anything sudden, spreading, or breathing-related is an emergency regardless of which compound caused it.
People also compare
This comparison does not cover cost, long-term safety, or how you personally will respond. Effect figures come from separate trials in different populations and are not always directly comparable to each other. Nothing here is medical advice or a recommendation to use any of these. Talk to a clinician about your own situation.