N-Acetyl Semax Amidate is a semax variant (nasal). DSIP is a sleep peptide.
They are aimed at different things: N-Acetyl Semax Amidate at focus & brain; DSIP at sleep.
| Comparison | N-Acetyl Semax Amidate NA Semax Amidate · NASA Semax | DSIP (Delta Sleep-Inducing Peptide) delta sleep-inducing peptide |
|---|---|---|
| How it works | How it works This is Semax with two chemical modifications, an acetyl group at one end and an amide at the other, both added to slow its breakdown. | How it works DSIP was isolated in the 1970s from the blood of sleeping rabbits, and half a century later nobody is certain what it does. |
| What it is | A longer-lasting version of Semax for focus and memory. | A before-bed peptide used to deepen sleep. |
| Status | Research only | Research only |
| Typical dose | 0.2–0.4 mg per day | 0.1–0.2 mg per dose |
| How often | 1-2x daily | Nightly |
| Dose comes from | Community practice | Community practice |
| Cycled? | Taken in courses, usually 10 to 14 days, with breaks between Community practice | No established schedule No established range |
| What it does | ||
| Drug class | Semax variant (nasal) | Sleep peptide |
| Used for | A longer-lasting, more stable version of Semax for focus, memory, and mental clarity. | A before-bed peptide used to deepen sleep and improve sleep quality without the grogginess of sleeping pills. |
| Receptors hit | — | — |
| Numbers | ||
| Full dose line | 0.2 up to 0.4 mg per day | 0.1 up to 0.2 mg per dose (start low, increase slowly) |
| Why that cycle | Same course pattern as Semax, which it is a longer-lasting version of. No controlled study has compared courses against continuous use. | No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree. |
| Weight / effect | Not measured in a trial | Not measured in a trial |
| Chain length | 7 residues | 9 residues |
| Common vial | 30 mg | 5 mg |
| Before you start | ||
| Route | Nasal spray | Under the skin (subcutaneous) |
| Do not use if | No formal contraindications established outside Russia Pregnancy | No modern controlled safety data exists Pregnancy |
What separates them
Proof behind the dose. Every dose here comes from community practice. Not one is backed by a published human study, which is worth knowing before you read the numbers as if they were equivalent.
How you take it. DSIP is injected. N-Acetyl Semax Amidate is taken nasal spray, so the milligram numbers are not comparable between them.
What doesn't differ: Neither has a measured effect size from a published trial, so there is no number to rank them on.
What people actually report
N-Acetyl Semax Amidate
- Mostly mild nasal irritation.
- No serious adverse events have been reported at studied doses
- Signs of an allergic reaction
DSIP (Delta Sleep-Inducing Peptide)
- Generally well tolerated, but results are inconsistent.
- Signs of an allergic reaction
- Anything unusual, given the thin data
Side effects are what users and trials report most often, not a complete list. Anything sudden, spreading, or breathing-related is an emergency regardless of which compound caused it.
People also compare
This comparison does not cover cost, long-term safety, or how you personally will respond. Effect figures come from separate trials in different populations and are not always directly comparable to each other. Nothing here is medical advice or a recommendation to use any of these. Talk to a clinician about your own situation.