CJC-1295 with DAC and CJC-1295 no DAC are each a copy of GHRH.
GHRH is the signal that tells your pituitary to release its own growth hormone.
They last very different lengths of time. CJC-1295 no DAC is gone in 30 minutes; CJC-1295 with DAC stays active for 6-8 days. That is why the schedules look nothing alike.
| Comparison | CJC-1295 with DAC CJC-1295 DAC · DAC:GRF | CJC-1295 no DAC (Mod GRF 1-29) Mod GRF 1-29 · Modified GRF 1-29 |
|---|---|---|
| How it works | How it works CJC-1295 copies GHRH, the hormone that tells your pituitary to make growth hormone. The DAC version carries a molecular anchor that keeps it circulating for days rather than minutes. | How it works This is the same GHRH copy as CJC-1295 with DAC, minus the anchor that makes it last. That one difference changes everything about how it behaves. |
| What it is | A once-or-twice-weekly shot that keeps your growth hormone raised for days. | A short-acting growth-hormone pulse, usually paired with ipamorelin. |
| Status | Research only | Research only |
| Typical dose | 1–2 mg per dose | 0.1 mg per dose |
| How often | 1-2x per week | Daily to 2x daily |
| Stays active | ~6-8 days | ~30 minutes |
| Dose comes from | Community practice | Community practice |
| Cycled? | Commonly cycled, usually 8 to 12 weeks on and 4 off Community practice | Commonly cycled, usually 8 to 12 weeks on and 4 off Community practice |
| What it does | ||
| Drug class | GH secretagogue (GHRH) | GH secretagogue (GHRH) |
| Used for | A long-acting shot that keeps growth hormone raised for days, used to build muscle, burn fat, recover, and sleep better. You inject it only once or twice a week. | The short-acting version that gives a quick growth-hormone pulse closer to your body's natural rhythm. It is usually paired with ipamorelin for muscle, fat loss, and recovery. |
| Receptors hit | — | — |
| Numbers | ||
| Full dose line | 1 up to 2 mg per dose (start low, increase slowly) | 0.1 mg per dose |
| Why that cycle | Commonly cycled 8 to 12 weeks on and 4 off, and no study has tested that. The argument for it is that this version holds growth hormone at a raised baseline rather than restoring pulses. Worth knowing that when GHRH itself was infused continuously for 14 days in people, the pituitary did not run down. So the tolerance case for cycling this one is an inference from related drugs, not something anyone has measured in it. | Because it clears in about half an hour it produces a pulse rather than a raised baseline, which is the argument users give for needing less of a break than the DAC version. Neither schedule has been tested. |
| Weight / effect | Not measured in a trial | Not measured in a trial |
| Chain length | 30 residues | 29 residues |
| Common vial | 5 mg | 5 mg |
| Before you start | ||
| Route | Under the skin (subcutaneous) | Under the skin (subcutaneous) |
| Do not use if | Active cancer Pregnancy Banned in drug-tested sport | Active cancer, as a precaution with anything raising growth hormone Pregnancy Banned in drug-tested sport |
What separates them
Proof behind the dose. Every dose here comes from community practice. Not one is backed by a published human study, which is worth knowing before you read the numbers as if they were equivalent.
What doesn't differ: They are both taken the same way (under the skin) and aimed at the same thing (recovery & muscle). Neither has a measured effect size from a published trial, so there is no number to rank them on.
What people actually report
CJC-1295 with DAC
- Because it keeps growth hormone up constantly instead of in natural pulses, effects and any side effects linger for days.
- It is not approved and is banned in drug-tested sport.
- Spreading hives, face or throat swelling, or trouble breathing
- New lumps or masses
CJC-1295 no DAC (Mod GRF 1-29)
- It clears in about half an hour, so it needs frequent dosing.
- It is not approved and is banned in drug-tested sport.
- Spreading hives, face or throat swelling, or trouble breathing
- New lumps or masses
Side effects are what users and trials report most often, not a complete list. Anything sudden, spreading, or breathing-related is an emergency regardless of which compound caused it.
People also compare
This comparison does not cover cost, long-term safety, or how you personally will respond. Effect figures come from separate trials in different populations and are not always directly comparable to each other. Nothing here is medical advice or a recommendation to use any of these. Talk to a clinician about your own situation.